Hazardous Biological and Chemical Technologies

"AI systems such as LLMs, chemical LLMs (Skinnider et al., 2021; Moret et al., 2023), and other LLM- based biological design tools might soon facilitate the production of bioweapons, chemical weapons, and other hazardous technologies. In particular, LLMs might enable actors with less expertise to more easily synthesize dangerous pathogens, while customized chemical and biological design tools might be more concerning in terms of expanding the capabilities of sophisticated actors (e.g. states) (Sandbrink, 2023). Gopal et al. (2023) and Soice et al. (2023) demonstrated that people with little background could use LLMs to help make progress towards developing pathogens such as the 1918 pandemic influenza. However, recent studies suggest that current LLMs are not more helpful than internet search in this regard (Mouton et al., 2024; Patwardhan et al., 2024)."